Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

Arthritis is a common degenerative disease of joints, which has become public health problem affecting human health, but its pathogenesis complex and cannot be eradicated. Coptis chinensis (CC) variety active ingredients, natural antibacterial anti-inflammatory drug. In which, berberine main effective ingredient, good therapeutic effects on rheumatoid arthritis (RA), osteoarthritis (OA), gouty (GA). RA, OA GA are the three most types arthritis, relevant not clear. Therefore, molecular mechanism prevention treatment key issues to paid attention in clinical practice. general, berberine, palmatine, coptisine, jatrorrhizine, magnoflorine jatrorrhizine hydrochloride CC play role treating by regulating Wnt1/β-catenin PI3K/AKT/mTOR signaling pathways. this review, targets were expounded, we have further explained potential AHR, CAV1, CRP, CXCL2, IRF1, SPP1, IL-17 pathway provide new idea for CC.